TR — 10mg/ 15mg/ 20mg/ 30mg/ 60mg

Dual GLP-1 / GIP Receptor Agonist | Advanced Metabolic Regulator, Satiety Control & Glycemic Optimizer

Overview:
TR (Tirzepatide) is a synthetic dual-action incretin mimetic designed to activate both Glucose-dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) receptors. By engaging both metabolic pathways simultaneously, TR enhances glucose-dependent insulin secretion, lowers glucagon levels, delays gastric emptying, and regulates central appetite pathways for profound body recomposition and glycemic balance.

This product is supplied as a sterile lyophilized powder in 10mg, 15mg, 20mg, 30mg, and 60mg multi-dose vial configurations and requires reconstitution prior to use.

Single-target GLP-1 agonists focus primarily on suppressing appetite and slowing digestion. TR expands on this mechanism by adding GIP receptor activation, which directly improves adipose tissue sensitivity, promotes lipid metabolism, and significantly reduces gastrointestinal side effects compared to traditional single-receptor compounds.

Offered in an extensive range of vial sizes—from 10mg up to high-capacity 60mg multi-dose vials—TR provides flexible options for both standard titration schedules and high-dose, long-term research cycles.

• Dual Incretin Activation (GLP-1 + GIP): Delivers superior glycemic control and appetite suppression compared to single GLP-1 mimetics.
• Targeted Adipose Reduction: Enhances lipid clearance and drives subcutaneous body fat breakdown.
• Potent Satiety Modulation: Delays gastric emptying to reduce appetite, control cravings, and lower daily calorie consumption.
• Insulin Sensitivity Optimization: Promotes glucose uptake in skeletal muscle and organ tissue while suppressing unnecessary glucagon output.
• Versatile Multi-Strength Range: 10mg to 60mg capacity options allow for precise titration and cost-effective extended protocols.

1. Reconstitute using Bacteriostatic Water (BAC).
2. Example: Add 2.0 mL of BAC Water to 10mg or 15mg vials, or 3.0 mL to 5.0 mL of BAC Water to 20mg, 30mg, and 60mg vials for manageable liquid unit concentrations.
3. Inject the BAC water slowly along the inner glass wall—do not squirt directly onto the lyophilized powder cake.
4. Gently swirl (do not shake) until the white powder dissolves completely into a clear liquid.
5. Store reconstituted TR in the refrigerator at 2°C – 8°C (36°F – 46°F) and use within 28 days.

For exact dose conversions and liquid volume planning, use our Reconstitution Calculator on the website.

Starting Titration Dose: 2.5 mg administered once weekly.

Escalation Protocol: Increase dose in 2.5 mg increments every 4 weeks based on tolerance and target protocol goals.

Administration Site: Subcutaneous injection once weekly into the lower abdomen, upper thigh, or outer arm.

Protocol Duration: Cycles typically run 12 to 24+ weeks with gradual dose escalation.

Monitoring & Considerations:

• Common Considerations: Mild, temporary gastrointestinal adaptation effects such as nausea, fullness, or light indigestion during initial dose escalations.
• Monitoring: Regularly check fasting blood glucose, body composition metrics, blood pressure, and hydration status.
• Contraindications: Personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).