MOTS-C — 10mg / 40mg

Mitochondrial-Derived Peptide | Cellular Energy Regulator & Exercise Mimetic for Metabolic Optimization

Overview:
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a novel 16-amino acid peptide encoded within the mitochondrial genome. Functioning as a potent metabolic regulator, MOTS-C translocates to the cell nucleus during metabolic stress to control gene expression, enhance insulin sensitivity, drive fatty acid oxidation, and optimize cellular energy production via AMPK pathway activation.

This product is supplied as a sterile lyophilized powder in 10mg and 40mg vial configurations and requires reconstitution prior to use.

Unlike traditional peptides that target cell-surface hormone receptors, MOTS-C directly regulates energy metabolism at the cellular level by mimicking the biological physiological benefits of exercise.

It targets skeletal muscle tissue to promote glucose uptake independent of insulin while stimulating mitochondrial biogenesis. Available in flexible 10mg and high-capacity 40mg strengths, MOTS-C offers an exceptional solution for intensive metabolic research, endurance optimization, and anti-aging protocols.

• AMPK Pathway Activation: Triggers central metabolic master regulators to increase cellular energy and metabolic flux.
• Glucose Homeostasis & Insulin Sensitivity: Enhances glucose clearing and uptake in skeletal muscle tissue.
• Fatty Acid Oxidation: Promotes the breakdown of stored lipids for fuel, supporting lean body recomposition.
• Exercise Mimetic Effects: Simulates systemic metabolic adaptations typically achieved through high-intensity resistance or cardiovascular training.
• Mitochondrial Health & Longevity: Protects against metabolic decline, oxidative stress, and age-related cellular fatigue.

1. Reconstitute using Bacteriostatic Water (BAC).
2. Example: Add 2.0 mL of BAC Water to a 10mg vial for a 5.0 mg/mL solution, or 4.0 mL to a 40mg vial for a 10.0 mg/mL solution.
3. Inject BAC water slowly along the inner glass wall—do not squirt directly onto the lyophilized powder cake.
4. Gently swirl (do not shake) until the white powder dissolves completely into a clear liquid.
5. Store reconstituted MOTS-C in the refrigerator at 2°C – 8°C (36°F – 46°F) and use within 28 days.

For precise reconstitution and dosage calculations, use our Reconstitution Calculator on the website.

Standard Protocol: 5 mg to 10 mg administered 1 to 3 times per week.

Timing: Administer via subcutaneous injection prior to physical activity or in the morning on an empty stomach.

Administration Site: Subcutaneous injection into the abdomen or upper thigh region.

Protocol Duration: Cycles typically run 4 to 8 weeks, followed by a rest period.

Monitoring & Considerations:

• Common Considerations: Mild localized injection site tightness or temporary warmth post-injection.
• Monitoring: Periodically check fasting blood glucose, insulin markers, and hydration levels.
• Contraindications: Severe hypoglycemia or acute metabolic instability without proper monitoring.